When several people die suddenly and without warning five years after receiving transplants from a single organ donor, House and the team rush to save the only two surviving recipients. With one already dying and the other healthy but sure to fall ill at any moment, the team must find out what was wrong with the original organ donor. As the team sorts through the records on the deceased donor recipients to find the common thread, they must deal with a new intrusion. House has hired Lucas (guest star Michael Weston), a private investigator, to dig up information about the deceased despite the team’s skepticism. Meanwhile, House auditions new best friends to replace Wilson, and soon uses Lucas for his own personal means to spy on Wilson and the other team members.