Intermittent Fasting vs. Prolonged Fasting: Benefits of 1-3 Day Fasts- Thomas DeLauer

Intermittent Fasting vs. Prolonged Fasting: Benefits of 1-3 Day Fasts- Thomas DeLauer… Learn some of my Fasting Protocols with me 1:1
Prolonged fasting (PF) is that which lasts from 48 hours to 120 hours-
Studies have found that fasting:
Reduces oxidative damage and inflammation
Promotes optimal energy metabolism
Protects cells

In humans benefits include:
Weight loss
Arthritis benefits
Asthma improvement
Helps with hypertension

Prolonged fasting has been demonstrated to:
Increase cellular resistance to toxins in both human and mice studies
Reduces circulating insulin-like growth factor 1 (IGF-1)
Protect cells from chemotoxicity (for example those who undergo chemotherapy)

Differences between PF and fasting of less than 24 hours are likely due to the complete exhaustion of glycogen. Our liver stores most of our body’s glucose in the form of glycogen.

Following 12 o 24 hours of fasting (varies by person and factors such as physical fitness), liver (hepatic) glycogen stores are depleted and the body turns to the following for energy:
Nonhepatic glycogen stores
Free fatty acids
Ketone bodies

Humans can survive 30 or more days fasting. This way of producing energy may slow cellular aging in mammals. It is natural for humans to have high energy when hungry and lower energy when satiated – likely because we would have needed our brains functioning well to come up with new sources of food.
Hunger creates a cascade of bodily processes that may explain the benefits of fasting. When we are hungry, certain hormones are released and neuronal networks activated. The hunger response leads to increased activity in the neuronal networks related to cognition.
This leads to:
Production of BDNF (brain-derived neurotrophic factor)
Synaptic plasticity improvement
Stress tolerance increase

Cardiovascular benefits are likely due to the increased levels of adiponectin during fasting
Adiponectin is released from fat cells. Obese individuals have less circulating adiponectin than normal weight individuals. Too little adiponectin is tied to many chronic diseases, including type-2 diabetes, metabolic syndrome, non-alcoholic fatty liver disease, cancer and heart disease. Adiponectin in an anti-inflammatory agent and protects against chronic disease. Hypertension has been helped in a human study with 13 days of water only fasting, and the benefits even remained when blood pressure was tested following 6 days of normal eating. Fasting for 3 or more days leads to changes in insulin, IGF-1, IGFBP-1 and glucose:
30% or greater decrease in plasma insulin and glucose levels
Decrease in IGF-1, the major growth factor in humans
High IGF-1 and insulin levels are tied to aging and cancer
Increase in IGFBP-1 (a protein that inhibits IGF-1)

Longer fasting periods have shown impressive results for those with rheumatoid arthritis
Best results are with a fasting periods of 1-3 weeks followed by a vegetarian diet.

Immune system benefit:
Fasting for 3 days or longer leads to a reset of the immune system
Fasting lowers white blood cell counts, leading to new white blood cells being created by the immune system
A study took cancer patients who were undergoing chemotherapy and had them fast for 1, 2 or 3 days prior to chemotherapy.
Those who fasted for 3 days, but not those who fasted for 1 day, experienced fewer harmful side effects, such as immunosuppression .Many positive effects have been found for both prolonged fasting as well as intermittent fasting, so incorporating either into your routine will likely be beneficial.

*It is very important to speak with your doctor before going on a fast lasting 3 or more days. Longer fasts may not be advised for those who are underweight, young or old.

1. Prolonged fasting reduces IGF-1/PKA to promote…

2. Fasting: molecular mechanisms and clinical applications

3. Adiponectin


44 thoughts on “Intermittent Fasting vs. Prolonged Fasting: Benefits of 1-3 Day Fasts- Thomas DeLauer

  1. Make sense…but….I wanted to be focused for study (!!) not for searching food !! I'm not sure if i've noticed the ,,mind clarity_"effect (many people said that about fasting, in general)…It works some periods…..but as in the clip said ,,focus…." (but for searching food!!)) and less for study !! — so ,,logically" 😉 ….if you want focus for study i recommend you to fast 18-20 hours and eat 2 times in 6-4 hours….Sometimes you can prolong to 40 -48 hours….but after that is more difficult to study….

  2. Usually i eat once a day. For 2 years now. When i eat meat, witch is once a week, or 2 weeks, i eat fruits 2 to 3 hours before. And do 40 hours dry fast weekend. Do You think is effective what i do ??? BIG BRAIN IMPROVEMENT SO FAR. But i stopped consuming ALL these modern veggie oils, sitch are VERY INFLAMATORY.

  3. hello people!

    I have a question about prolonged fasting.

    First of all I am doing OMAD for over a year and my body is fully adapted to fasting. But Ι never did a fast of more than 48 hours.

    Now I am in the middle of a 5 day water fast or maybe more. But I am questioning the benefits.. What if a break my fast once a day, with a no more than 300 calories, sallad? Just some greens, olive oil and salt. Surely it would break my fast but it would give me vitamins and minerals. Will it do more harm than good? thank you

  4. When doing the prolonged fasting or even intermittent fasting, is it important to consume your full Daly caloric intake requirement? Or should we still eat a reduced caloric meal?

  5. I did a 48 hour trial. I was not hungry and felt very positive. today I ate some roast beef and avocado and crashed hard. I have not been tired like that in so long. I'm going for 72 hours now. I got to see what all the hype is about

  6. Great Information. i intermittent fasted from the day after Thanksgiving, where I weighed 233 lbs. until this past Tuesday. I had 1 meal a day for that time period and my weight went down to 220 lbs. Then on Tuesday i did a prolong fast drinking only water and black coffee for approximately 36 hrs until Thursday evening where I had 1 very small meal. The energy and alertness was off the charts after 24 hrs. and I really was not hungry. On Thursday morning i weighed in @ 217 lbs. i'm 65 years old. 6ft tall with about 20 t0 30% body fat. My goal is 190 -200. What I wanted to know was how it affected me and why I was all of a sudden so alert and energized. Thomas just explained that beautifully in the 2 videos. I'll never eat again….just kidding. Gotta get rid of this spare tire.

  7. Good morning Mr. Delauer, I'm on my 7th day of my Water Fasting, and I'm feeling pretty good so far. But the last 2 day I've been the same weight, can you tell me if it'll change? I checked my Keton levels and my body is on Ketosis, that dark purple🤷🏽‍♀️, and haven't broke my fast at all, and so far since Nov.9th I've lost 15lbs.. yaaayyyy me, I don't want to get discouraged, so if you give me some advice please.. Or anyone that has experienced this, did your weight break?

  8. I do IF since 4 years a go, and in 2018 I already did twice a water fast for 48 hours, but know I´m trying to do a 72 hours Water fasting (just water, not tea or cofe, just mineral water). And my goal is to do the 5 days water fasting, after Crystmas, I thing is a good time to do it.

  9. My biggest concerns when it comes to prolonged fasting are: dealing with hunger pangs (the physical sensations are very uncomfortable and distracting), and dealing with the dizziness/light-headedness. I've only attempted a 24-hour fast once and ended it early for those two reasons. I did try to use water to deal with the hunger pangs but they did not stop even when my stomach was full of water so I'm not sure what else might be good to try.

    Aside from that, this video presents some really great perspectives and things to consider. The stress tolerance bit is the most interesting to me, and the synapse elasticity makes sense (if your brain thinks you're starving, it may try to 'think' its way out of the problem, requiring it to devote more resources to cognition – especially the problem-solving abilities of the brain).

  10. I'm in the end of my third day of water fasting and honestly feel like shit. My mind is clear and all but my blood pressure and heart rate is way too low and i'm feeling lethargic. Does anyone have any idea why?

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